Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

Sunday, August 17, 2025 12:00 AM

Conditions: Pancreatic Adenocarcinoma; Cancer of the Pancreas; Pancreas Cancer; Pancreatic Cancer Interventions: Radiation: Stereotactic body radiotherapy; Drug: Defactinib; Drug: Avutometinib Sponsors: Washington University School of ...

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

Thursday, August 14, 2025 12:00 AM

Conditions: Atrial Fibrillation Interventions: Device: Apple Watch: AFib History; Device: Zio Patch Sponsors: The Cleveland Clinic; Washington University School of Medicine Recruiting

This Study Involves a Positron Emission Tomography (PET) Scan Using a New Investigational Radioactive Tracer, [18F]-FZTA, to Detect Inflammation in the Brain. The Tracer Will be Tested in Healthy Younger Adults and Individuals With Multiple Sclerosis.

Monday, August 11, 2025 12:00 AM

Conditions: Multiple Sclerosis Interventions: Drug: [18F] FZTA Sponsors: Washington University School of Medicine Recruiting

Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction

Monday, August 11, 2025 12:00 AM

Conditions: ACL Injury; ACL Tears; ACL Surgery Interventions: Drug: Tranexamic Acid (TXA); Drug: Placebo Sponsors: Campbell Clinic; Duke University; University of Pittsburgh; Endeavor Health; University of Cincinnati; Washington University ...

Impact of an Electronic Health Record Maintenance Alert on PSA Screening Rates in a 10-Hospital Integrated Health System

Sunday, August 17, 2025 12:00 AM

Conditions: Prostate Cancer; Cancer of the Prostate Interventions: Other: Annual PSA Health Maintenance Reminder Sponsors: Washington University School of Medicine Recruiting

CA-4948 in Combination With Cisplatin, Gemcitabine, and Durvalumab in Patients With Untreated Advanced or Metastatic Biliary Tract Cancer

Wednesday, August 6, 2025 12:00 AM

Conditions: Metastatic Biliary Tract Cancer; Metastatic Biliary Tract Carcinoma Interventions: Drug: CA-4948; Drug: Gemcitabine; Drug: Cisplatin; Biological: Durvalumab Sponsors: Washington University School of Medicine; Curis, Inc.; Washington ...

Substance Use in Pregnant People - Optimizing Retention in Treatment

Tuesday, August 19, 2025 12:00 AM

Conditions: Substance Use Disorder (SUD); Pregnancy; Postpartum; Contingency Management Interventions: Other: Social drivers of health screening; Behavioral: Patients will undergo a program of contingency management Sponsors: Washington ...

Effect of Ketone Esters on Liver Fat Content and Metabolic Function

Friday, August 15, 2025 12:00 AM

Conditions: MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity Interventions: Drug: bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester); Other: Placebo Sponsors: Washington University School of Medicine; Children's ...