Using Personalized Rehabilitation to Reduce Disease and Increase Activity of Patients With Polymyalgia Rheumatica

Thursday, August 6, 2026 12:00 AM

Conditions: Polymyalgia Rheumatica (PMR) Interventions: Behavioral: Movement Pattern Training (MoveTrain); Other: Usual Care Sponsors: Washington University School of Medicine Not yet recruiting

Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor

Tuesday, August 4, 2026 12:00 AM

Conditions: MPNST (Malignant Peripheral Nerve Sheath Tumor) Interventions: Drug: avutometinib capsule + defactinib tablet Sponsors: Girish Dhall, MD; United States Department of Defense; Children's Hospital of Philadelphia; Washington ...

Emergency Medicine Practitioners Overall Well-being Enhancement With Ambient AI Scribes

Thursday, August 6, 2026 12:00 AM

Conditions: Well-being at Work; Burnout Interventions: Other: Ambient AI Scribe Sponsors: Washington University School of Medicine Active, not recruiting

Personalized Antisense Oligonucleotide Therapy for Participants With TARDBP ALS

Monday, August 3, 2026 12:00 AM

Conditions: Amyotrophic Lateral Sclerosis (ALS) Interventions: Drug: nL-TARDB-006 Sponsors: n-Lorem Foundation; Columbia University; Washington University School of Medicine Enrolling by invitation

Semaglutide for Low Back Pain

Tuesday, July 28, 2026 12:00 AM

Conditions: Lower Back Pain; Obesity (BMI>30); Chronic Lower Back Pain; glp1 Agonist Interventions: Drug: Semaglutide (administered by PDS290 pen-injector); Drug: Placebo (administered by PDS290 pen-injector) Sponsors: Washington University ...

A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease

Tuesday, August 4, 2026 12:00 AM

Conditions: Parkinson's Disease (PD) Interventions: Device: Digital Music Device (MedRhythms, Inc., Portland, ME) Sponsors: Boston University Charles River Campus; Michael J. Fox Foundation for Parkinson's Research; University of Utah; ...

Lumateperone for Late-Life Depression

Thursday, August 6, 2026 12:00 AM

Conditions: Treatment Resistant Depression (TRD); Late Life Depression (LLD); Depression / Major Depressive Disorder Interventions: Drug: Lumateperone; Drug: Placebo Sponsors: Eric Lenze; Intra-Cellular Therapies, Inc.; Washington University ...

HFrEF Polypill in Sri Lanka RCT

Friday, August 7, 2026 12:00 AM

Conditions: Heart Failure With Reduced Ejection Fraction Interventions: Other: Usual Care; Drug: HFrEF Polypill Sponsors: Washington University School of Medicine; Centre for Chronic Disease Control, India; National Heart, Lung, and Blood ...